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Ghulam Rasool Mashori

Ghulam Rasool Mashori

University of Medical & Health Sciences for Women, Pakistan

Title: Lisinopril an ACE inhibitor and its effect on Insulin Release.

Biography

Biography: Ghulam Rasool Mashori

Abstract

Hypertension is a persistent raise of resting systolic (≥140mmHg) & diastolic (≥90mmHg) BP (Carretero & Operil, 2000). In normal individuals BP ranges from 120/80mmHg to 140/90mmHg (ISH, 2014). Coronary Heart Diseases (CHD) develops more in diabetic hypertensives than in non-diabetics (James et al., 2000). CHD is the main cause of deaths worldwide. Management of hypertension has decreased the occurrence of stroke, heart failure & renal failure, however events of CHD has not been decreased to that level. On the contrary many antihypertensive drugs have diabetogenic effects via suppression of insulin.  The purpose of the study was to observe effects of Lisinopril on insulin release by using rat isolated pancreas (Loubatieries et al., 1972). Diazoxide was used as positive control i.e. known Insulin suppressant drug. Dose used was based on therapeutic peak plasma concentration. Lisinopril at peak plasma level (150ng/ml), did not inhibit Insulin secretions significantly. In conclusion, at peak plasma level Lisinopril did not show any negative effect on Insulin release.